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30,53,61 Data Sources: Search in MEDLINE and CINAHL for joint hypermobility (in general, including EDS) and epidemiolog$.mp, risk factors, (pathogenesis or pathogenetic or pathogenic$ or pathogeny).mp, clinical presentation, symptoms, diagnosis, diagnostic criteria, clinical management or prognosis limiting to English and the past 10 years with additional review of bibliographies for relevant articles

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Addressing systemic inflammation through dietary changes, sleep optimization, and stress management creates a more favorable environment for peptide-mediated brain repair