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(2021, March 17)

Similar observations were made in aortic tissue slices, where FOXO4-DRI treatment led to increased expression of p-P53, mainly localized in the cytoplasm (Figures 5F,G)

4.2 Mechanistic complexity and polypharmacology One challenge lies in the very strength of TCM metabolites: their polypharmacology (ability to hit multiple targets)