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For instance, food-based dietary guidelines could be updated to include specific, mechanism-aware advice, such as recommending one serving of cruciferous vegetables three to four times per week to leverage Nrf2 activation, or promoting the inclusion of fermented foods like yogurt or kimchi to support gut health via microbial metabolites

Randomized studies have supported its use as monotherapy in appropriate patients, and it is often included as part of combination protocols

In neurodegenerative disease, the histone acetylation homeostasis is significantly compromised, shifting towards hypoacetylation (Saha and Pahan, 2005)

Wong EL, Stowell RD, Majewska AK