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UK to ban single-use vapes starting June 1, 2025, across England, Scotland, Wales, and Northern Ireland , permitting only rechargeable and refillable devices, with penalties varying by region: 200 fine for first offenses in England (up to 2 years in prison for repeat violations), fines up to 5,000 in Scotland and Northern Ireland, and fines starting at 200 in Wales, driven by environmental concerns and the aim to reduce illicit products
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When nicotinic receptors in the brain are suddenly deprived of nicotine, the release of the feel-good neurotransmitter dopamine also halts and this is when the trouble starts, too
Smoking also triggers oxidative stress, mitochondrial injury, and chronic liver inflammation, which are central to disease progression [61, 66]
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