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Some observational research has also suggested a slight increase in lung cancer risk linked to long-term, high-dose B6 and B12 supplementation, particularly among men and smokers, although this kind of study cannot prove that the supplements caused the cancers

A 2016 study published in Nature Medicine demonstrated that MOTS-c administration improved insulin sensitivity and reduced diet-induced obesity in mouse models, even when started after metabolic dysfunction was already established

Vitamin B6 and vitamin B12 are two examples of B complex vitamins, that if taken in high doses, can increase neurotransmitter levels, and consequently, possess stimulating properties

doi: 10.1039/c2mt00171c