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Drug design challenges Several issues must be addressed concerning the development of an efficacious drug to treat AD: (1) the drug must penetrate the BBB to influence damaged neurons in memory-associated brain structures

The synthetic derivative of curcumin biphenyl-difluoroketone (EF24) has been reported to trigger cell apoptosis, restrain cell growth, and diminish metastatic capabilities (194, 195)

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Individuals experiencing brain fog may also report distractibility, forgetting intentions (e.g., the reason for entering a room), and struggling to switch between tasks [7]